Early Phase Clinical Trials 2015

This program is a unique and innovative funding opportunity designed to help outstanding Canadian researchers accelerate the development of safer and more effective treatments for neurodegenerative diseases of aging. Projects should have demonstrated excellent preliminary data and be focused on generating results to support the next stage of clinical trials.

Early Phase Clinical Trials 2015 Awardees

Effect of long-acting levodopa on obstructive sleep apnea in Parkinson’s disease

Grantees: Dr. Marta Kaminska , Dr. Andrea Benedetti , Dr. John Kimoff , Dr. Anne-Louise Lafontaine

Project description Sleep disorders are common in Parkinson’s disease (PD), including obstructive sleep apnea (OSA). OSA consists of recurrent complete or partial obstruction of the upper airway (throat) during...


A phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia

Grantees: Dr. Elizabeth Finger , Dr. Adam Boxer , Dr. Jeffrey Cummings , Dr. Howard Feldman

Project description Frontotemporal dementia (FTD) is a progressive neurodegenerative disease for which there is presently no available cure, and only a few off-label symptomatic treatments that are marginally effective....


Safety and efficacy of a novel amyloid-clearing therapeutic KAL-ABP-BBB in early Alzheimer’s disease patients

Grantees: Dr. Pedro Rosa Neto , Michael Waterston , Dr. Balu Chakravarthy , Dr. T. Nathan Yoganathan , Dr. Danica Stanimirovic , Dr. Serge Gauthier , Dr. Angela Genge

Project description The accumulation of the protein amyloid-beta constitutes the major abnormality in the brain of Alzheimer’s disease patients. This award will support a clinical trial for assessing the...