Early Phase Clinical Trials: Canada

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*We are currently not accepting applications to the Early Phase Clinical Trials: Canada program*

Neurodegenerative diseases of aging are among the least understood and most undertreated diseases today. Diseases such as Alzheimer’s and Parkinson’s are placing a large and increasing burden on society. If ignored, the social and economic costs of managing these diseases will rise significantly within a generation. Meeting these challenges requires pioneering approaches to accelerating treatments.

The Early Phase Clinical Trials: Canada program was created to provide funding support for clinical trials and clinical trial sub-studies with excellent preliminary data.

Continuing for 2020:

  • Applications focused on complementary approaches (e.g., diet, physical activity, sleep, speech therapy, cognitive therapy) are eligible for the Early Phase Clinical Trials program, if they meet our other program scope criteria and have specific supportive evidence/justification (from published literature or unpublished data) to warrant further investigation. Please refer to Institute definitions on complementary approaches for more details.
  • The Early Phase Clinical Trials: Canada program runs on a rolling basis. Applicants may submit an LOI at any time and will be notified of whether to prepare a full Proposal within ~2 months of LOI submission.
  • See our participant recruiting suggestions for ways of strengthening your recruiting plan in your proposal, and making recruiting faster and easier.

Program Overview

Please refer to the Program Details  and Request for Applications (RFA) documents for more information (last updated: January 22, 2020).

Goal: To provide funding to support clinical trials and/or clinical trial sub-studies that could accelerate the development of therapeutics for neurodegenerative diseases of aging.

Funding: A maximum of $1,500,000 per project over up to 4 years. If you are requesting a budget between $1.5 to $2 million per project, please contact Cristina Tang (cristina.tang@westonbrain.org) prior to applying.

Applicant Eligibility
Eligible Principal Applicants must meet all of the criteria below:

  • Be a researcher currently working in Canada at least 30% of the time.
  • Be at or above the level of Assistant Professor or equivalent.
  • Be affiliated with a Canada Revenue Agency-qualified donee institution located in Canada.

Co-applicants and Collaborators must be at the post-doctoral level or above, and can be working outside Canada.
Applicants may appear in any role on any number of projects.

Project Eligibility
Projects must meet these conditions to be eligible:

  • Be a clinical trial(s) and/or a clinical trial sub-study(s) that accelerates the development of therapeutics for neurodegenerative diseases of aging.
    • Projects that require only up to $300,000 over up to 18 months may also be submitted to the Rapid Response program.
    • Translational research other than clinical trials and/or clinical trial sub-studies should be submitted to the Transformational Research program or the Rapid Response program.
  • Be the development of a therapeutic and/or tool, and/or complementary approaches.

Please refer to the What We Fund page for Institute definitions of neurodegenerative diseases of aging, translational research, therapeutic, tool, complementary approaches, and clinical trials.

The Institute welcomes additional inquiries about this program, including whether a potential idea is in scope. Please contact Cristina Tang at cristina.tang@westonbrain.org or 416-967-7823.

Application Process

There are two stages to the application process:

  1. Letters of Intent (LOI)
  2. Proposal

An application requires the submission of a Letter of Intent which will be reviewed by our scientific review committee. Applicants with high potential projects will then be invited to submit a Proposal. Instructions for submitting the Proposal will be forwarded to those invited.

Applicants can expect to receive the outcome of their LOI application within ~2 months of submission.

Program Details (Updated Jan 22, 2020)

Request for Applications (RFA) (Updated Jan 22, 2020)

Letter of Intent sample (Updated Jan 22, 2020)




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