Dr. Gary Landreth

Dr. Landreth is a Professor of Neurosciences and Neurology and the Director of the Alzheimer Research Laboratory at Case Western Reserve University, School of Medicine.

Gary Landreth received his undergraduate degree in Chemistry and Biochemistry from the University of Kansas in 1972.  He then completed a Ph.D. in the Neuroscience Program at the University of Michigan, including a year of study at the National Institute of Medical Research in London.  He carried out postdoctoral work in the Department of Neurobiology at Stanford. Dr. Landreth was appointed to the faculty of the Medical University of South Carolina, where he worked for 9 years. He moved to Case Western Reserve University and the Alzheimer Research Laboratory in 1989 and is currently a professor in the Department of Neurosciences.

Dr. Landreth’s work over the past 20 years has focused on investigation of inflammatory mechanisms in Alzheimer’s disease and the biology of microglia. The laboratory is also involved in investigation of lipid metabolism in the brain and its roles in the biology of Alzheimer’s disease. The laboratory studies the actions of type II nuclear receptors in facilitating amyloid clearance from the brain. The laboratory maintains a focus on drug development for CNS disorders, including Alzheimer’s disease. His laboratory also investigates the development basis of autism and has developed animals of this disorder.

2014 Gary Landreth Advisor Fellow: Dr. Monica Holley, Bexarotene improves behavior and neuron health in 5XFAD mice

2015 Gary Landreth Advisor Fellow: Dr. Monica HolleyEnhanced macrophage clearance of amyloid using nuclear receptor agonists

2016 Gary Landreth Advisor Fellow: Dr. Miguel Moutinho, Actions of Nuclear Receptors on TREM2+ myeloid cells and in microglia in the AD brain