Transformational Research: Canada 2019 (Parkinson’s & Related Diseases / Alzheimer’s & Related Diseases)

Submit A Letter of Intent

Sign in to our online system or register for a new account to submit a letter of intent.

Apply Now

Neurodegenerative diseases of aging are among the least understood and most undertreated diseases today. If ignored, the social and economic costs of managing these diseases will continue to rise. Meeting these challenges requires pioneering approaches to accelerating treatments.

The Transformational Research: Canada program funds transformative, novel, high-risk, high-reward translational research projects.

Projects can be from $200,000 to $1,500,000.

Note: The program dates for the Parkinson’s & Related Diseases stream have been extended. The deadline for LOIs is now May 15, 2019. Please refer to the important dates section below.

NEW for 2019:

For the Transformational Research: Canada 2019 program, no preliminary data is required; instead it can be collected as an initial milestone with well defined, quantifiable go/no-go criteria. The structure of the project and budget should match the quality of the preliminary data.

Expanding the type of complementary approaches eligible for funding to other lifestyle interventions including but not limited to: speech therapy, cognitive therapy, music therapy, social interaction, if these applications meet our other scope criteria and have specific supportive evidence/justification (from published literature or unpublished data) to warrant further investigation.

Encouraging applications that bring in other fields such as: AI, big data, machine learning, data science, and computer science.

Program Overview

Goal: To provide funding for translational research that will accelerate the development of therapeutics for neurodegenerative diseases of aging.

Funding: A maximum of $1,500,000 over up to 3 years per project. Encouraging applications at all funding levels from $200,000 to $1,500,000, without need for preliminary data.

Applicant Eligibility: Eligible Principal Applicants must be researchers working in Canada at least 30% of the time at or above the level of Assistant Professor or equivalent, and be affiliated with a Canada Revenue Agency-qualified donee institution located in Canada. Co-Applicants/Collaborators must be at the post-doctoral level or above and can be working outside Canada.

Applicants may appear in any role on any number of projects.

Project Eligibility: Projects must meet the following conditions to be eligible:

  • Be translational research (excluding clinical trials and clinical trial sub-studies) that accelerates the development of therapeutics for neurodegenerative diseases of aging.
    • Clinical trials and clinical trial sub-studies should be submitted to the Early-Phase Clinical Trials or Rapid Response programs; however other translational research using humans or human samples/data is in scope.
  • Be the development of a therapeutic and/or tool and/or select complementary approaches (Please refer to the AD/PD Program Details for more information on complementary approaches that are in scope)

The project structure (i.e. the frequency and detail of the go/no go milestones) and the quality of the preliminary data should commensurate with the size of budget. For example: A project requesting $1,500,000 for 3 years should have strong preliminary data and multiple go/no-go milestones, whereas a project requesting $200,000 could have minimal preliminary data and less frequent milestones.

Please refer to What We Fund for Institute definitions of neurodegenerative diseases of aging, translational research, therapeutic, tool, and complementary approaches.

NEW for 2019: The Transformational Research program will have multiple calls per year, alternating between two different disease groups (outlined below). Applicants should apply to the group best suited to their project.

Alzheimer’s & Related Diseases: Parkinson’s & Related Diseases:
o Alzheimer’s disease o Parkinson’s disease
o Frontotemporal dementia o Dementia with Lewy bodies
o Mild cognitive impairment o Multiple system atrophy
o Vascular contributions to the above o Progressive supranuclear palsy
o Prodromes to the above o Vascular contributions to the above
o Prodromes to the above

The Institute welcomes additional inquiries about this program, including whether a potential idea is in scope. For questions related to the Parkinson’s & Related Diseases program, please contact Matthew Sacheli. For questions related to the Alzheimer’s & Related Diseases program, please contact Rene Prashad.

Application Process

There are two stages of the application process:

  1. Letter of Intent (LOI)
  2. Full Proposal

An application requires the submission of a Letter of Intent which will be reviewed by our scientific review committee. Applicants with high potential projects will then be invited to submit a Proposal. Instructions for submitting the Proposal will be sent to those invited.

Parkinson’s & Related Diseases (PD, PSP, DLB, MSA, prodromes, and vascular contributions to the listed diseases)

Program Details

Request for Applications (RFA)

LOI Sample

Alzheimer’s & Related Diseases (AD, FTD, MCI, and vascular contributions and prodromes to the listed diseases)

Program Details

Request for Applications (RFA)

LOI Sample

Apply Now

Important Dates

Parkinson’s & Related Diseases: Note: The program dates have been extended. The deadline for LOIs is now May 15, 2019.
Program opens: Currently Open
LOI deadline: May 15, 2019 at 2:00pm EDT
Proposal deadline: September 25, 2019 at 2:00pm EDT
Anticipated award notification: December 2019
Alzheimer’s & Related Diseases:
Program opens: Program is now closed
LOI deadline: April 1, 2019 at 2:00pm EST
Proposal deadline: July 30, 2019 at 2:00pm EDT
Anticipated award notification: October 2019

Program Information Webinar

The Institute will hold a Program Information Webinar for each disease focus, to provide further details on the program and answer any questions. However, if you have questions specific to your project (e.g., project scope), we encourage you to contact us.

Parkinson’s & Related Diseases: April 3, 2019 at 1:00pm EDT
Webinar has now passed

Alzheimer’s & Related Diseases: February 27, 2019 at 1:00pm EST
Webinar has now passed

Follow-on Funding

Funding (up to $1.5m) to grantees outside the regular granting mechanism in order to avoid delays in supporting exciting, potentially high-reward work based on previous success for grants awarded by the Weston Brain Institute.

If you’re a current or past Institute grantee, and would like to apply for follow-on funding, please visit the Weston Brain Institute Follow-on Funding page for more details on how to apply.


Back to Programs