Intermittent bilateral intraputamenal treatment with GDNF
MedGenesis Therapeutix Inc.
Researchers have developed a novel approach to delivering GDNF to the putamen by a process called convection-enhanced delivery (CED). This approach is aimed to optimize drug distribution within the putamen while minimizing exposure to drug in other areas of the brain. The approach integrates the use of four distinct components: a customized, implantable catheter system for convenient repeat treatment at the neurologist’s office; a specialized surgical planning software for optimized catheter placement; magnetic resonance imaging (MRI) technology to visualize the actual drug distribution in the putamen; and a new intermittent dosing scheme for optimized delivery of GDNF.