f-MRI study to elucidate mechanism of function of Deep Brain Stimulation (DBS) in Parkinson disease

2016  -  Toronto, ON, CA


Toronto Western Hospital

Supervising Advisor: Dr. Andres Lozano

Project summary:

Deep Brain Stimulation (DBS) is proven to be an effective therapy in appropriately selected Parkinson’s disease (PD) patients. Though the DBS is a surgical intervention but it is reversible and externally programmable. The surgery consists of implantation of electrode to specific target in the brain and placement of a pulse generator (pacemaker) to elicit a localized electrical field. This electrical field modulates the brain function and restores the abnormal movement. Though there is wide experience of DBS in PD, but how DBS works is largely unknown.

My current research work is focused to elucidate how DBS works. The research would involve specific magnetic resonance imaging (MRI) in DBS patient to explore mechanism of action of DBS in PD.