Developing a human neural model for Parkinson’s disease
University of Western Ontario
PD patients selected for deep brain stimulation will be invited to participate in this research. Cortical biopsies will be retrieved in the operating room and immediately processed for cell culture. Tissue processing conditions will favor growth of astrocytes, a form of glial cell known to retain the capacity to divide in the adult brain and recently implicated in PD. Culture conditions will be varied to test for growth of different cell types. Gene expression, growth and handling properties of the harvested cells will be evaluated.