Delayed start assessment of progranulin in a progressive rodent model of PD

2012  -  Charlottetown, PE, CA


Dr. Denis Kay



Project description

Here we propose to test the more clinically relevant treatment scenario of intervening with progranulin therapy after disease has been established, in a progressive pre-clinical model of Parkinson’s disease, a so called ‘delayed start’ intervention. We will again assess both behavioral and neuropathological indices of CNS health in pre-clinical models in which we will induce a PD-like disease over a period of 5 weeks. Once disease has been established we will treat the mode with progranulin and determine whether disease progression can be halted or blunted by the treatment.