Transformational Research 2013

While maintaining a focus on translational research accelerating therapeutics for neurodegenerative diseases of aging, this program complements the Rapid Response program by providing larger, longer grants for transformational work. This program was the first to provide funding for researchers to work with international collaborators and institutions on their projects, a feature now shared by most Institute programs.

Over 120 letters of intent were received and 12 were invited to the proposal phase. For the adjudication process, additional topic experts were added as reviewers to ensure an objective and comprehensive evaluation of proposals.

A total of $4.7 million was awarded to four projects. Grants range from $1.0 – $1.3 million per project given over three to five years.

Transformational Research 2013 Program Materials

2013 Transformational Research Awardees

Novel, low-cost focused ultrasound system for BBB disruption for the treatment of neurodegenerative diseases

Grantees: Dr. Kullervo Hynynen , Dr. Isabelle Aubert , Dr. Sandra Black

The overall goal of this proposal is to develop a clinical focused ultrasound device that can induce localized, controlled, and repeated opening of the Blood‐Brain Barrier (BBB) for the...


High-throughput behavioural platform to advance neurodegenerative disease drug discovery

Grantees: Dr. Marco Prado , Dr. Boyer Winters , Dr. Robert Bartha

Development of new drugs for Alzheimer’s disease depends on the use of animal models to test how well these drugs work before they are used in humans. Ideally new...


MRI-guided focused ultrasound therapy against amyloid-beta

Grantees: Dr. Isabelle Aubert , Dr. Kullervo Hynynen

The pathology of Alzheimer’s disease includes the accumulation of amyloid-beta peptides in the brain, leading to the formation of amyloid plaques and rendering the brain tissue unhealthy. Amyloid-beta peptides...