Targeted Diseases 2014: FTD/PSP

Targeted Diseases 2014 Program Materials

Targeted Diseases 2014 Awardees

Developing mouse models of FTD due to progranulin deficiency

Grantees: Dr. Blair Leavitt

Project description Mutations (genetic mistakes) in a gene that makes a protein called progranulin are an important cause of a very specific form of age-related brain degeneration called Frontotemporal...


A genomic-imaging analysis of the GENetic Frontotemporal dementia Initiative (GENFI): Development for a robust clinical trials platform

Grantees: Dr. Mario Masellis , Dr. Sandra Black , Dr. Elizabeth Finger , Dr. Joanna Knight , Dr. Robert Laforce , Dr. Bradley MacIntosh , Dr. Ekaterina Rogaeva

Project description There have been three major genes discovered that cause familial forms of frontotemporal dementia (FTD), a devastating group of disorders associated with personality and behavioural changes and/or...


Stabilization of ALS/FTD hexanucleotide repeats via modulation of repair to reverse disease progression

Grantees: Dr. Christopher Pearson , Dr. Gagan Panigrahi , Dr. Monika Schmidt , Dr. Neha Thakkar , Dr. Lisa Yu

Project description 40 human diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), myotonic dystrophy and Huntington’s disease, are inherited in a manner that the symptoms become more evident...