Rapid Response 2016

The Canada: Rapid Response 2016 program was created to catalyze and jumpstart the development of safe and effective treatments for neurodegenerative diseases of aging. The program provides short-term grants as seed funding for novel, high-risk, high-reward translational research projects for AD- and PD-related diseases.

Rapid Response 2016 Awardees

This list does not reflect all upcoming awardees. The awardees are listed once all documents have been finalized.

Reversing Hypervascularization in Alzheimer’s Disease Model

Grantees: Dr. Wilfred Jefferies

Project description Alzheimer’s disease (AD) is a well-known form of dementia. AD patients have deposits in their brains containing a protein called amyloid. Recently, we reported that amyloid causes...


Phase-Amplitude Coupling of Local Field Potentials in Subthalamic Nucleus in Parkinson’s disease

Grantees: Dr. Robert Chen , Dr. Neil Drummond

Project description Parkinson’s disease (PD) is one of the commonest neurodegenerative disorders and the prevalence of which is expected to increase with an aging population in Canada and worldwide....


Erythrocyte-derived extracellular vesicles: A biomarker of Parkinson’s disease progression

Grantees: Dr. Francesca Cicchetti , Dr. Eric Boilard , Dr. Richard Labib

Project description In recent years, there has been a dramatic surge of new findings that have fundamentally transformed our understanding of neurodegenerative diseases, in particular of Parkinson’s disease (PD)....


Validating O-glycosylation inhibitors as a disease modifying therapeutic strategy for Parkinson’s

Grantees: Dr. David Vocadlo , Dr. Omid Tavassoly

Project Description Currently there are no therapeutics that can slow or stop the progression of Parkinson Disease (PD). Accordingly, there is a major need to identify and advance promising...


Aprepitant for Harmful Irritability and Spontaneous Aggression in Dementia (AHIMSA-D)

Grantees: Dr. Jonathan Downar , Dr. Daniel Blumberger , Dr. Morris Freedman

Project Description Aggressive behaviour is a risky and burdensome symptom in many patients with dementia, and more effective, better-tolerated treatment options are needed.  Studies in animals suggest that the...


Re-engineering progranulin as an Alzheimer’s and FTD disease-modifying therapeutic

Grantees: Dr. Andrew Bateman , Dr. Hugh Bennett , Dr. Jagdeep Sandhu , Dr. Danica Stanimirovic , Dr. Jackalina Van Kampen

Project description Progranulin is a protein with important roles in the brain. Mutation of progranulin results in a disease called frontotemporal dementia in which parts of the brain, responsible...