Rapid Response 2015

The Rapid Response program was created to catalyze and jumpstart the development of safe and effective treatments for these diseases. The program provides short-term grants as seed funding for novel, high-risk, high-reward translational research projects. Proposed projects may relate to any disease; however, the basis for selection will be on the potential impact of the project on neurodegenerative diseases of aging.

Rapid Response 2015 Awardees

This list does not reflect all upcoming awardees. The awardees are listed once all documents have been finalized.

A smart multimodal neuroscience platform for enabling new drugs and innovative therapeutics against neurodegenerative diseases

Grantees: Dr. Benoit Gosselin , Dr. Yves De Koninck

Project description The future of drug discovery in neuroscience lies in developing the ability to assess, in a context sensitive manner, how each component of the enormously complex brain...


Development of a novel tissue engineered model of the cerebrovasculature

Grantees: Dr. Jerome Robert , Dr. Cheryl Wellington

Project description With every heartbeat, one quarter of all the blood in the body flows through the brain, and this activity is essential to keep neurons in the brain...


P2X7 Receptor: an apoE modulator and potential target in Alzheimer’s disease

Grantees: Dr. Iva Kulic , Dr. Cheryl Wellington

Project description Alzheimer’s Disease (AD) is the most common type of memory loss in the elderly. Apolipoprotein E (apoE) is a type of fat carrier in the brain and...


Combination therapy for vascular regeneration in a model of sporadic AD

Grantees: Dr. JoAnne McLaurin , Dr. Clifford Librach , Dr. Bojana Stefanovic

Project description In people, mid-life high blood pressure leads to brain vascular disease and late-life dementia even when blood pressure is normalized. Therefore we propose to examine the effect of...


Non-surgical transplantation of motor neuron-differentiated stem cells: A novel approach to the treatment of ALS

Grantees: Dr. W. Mark Erwin , Dr. Janice Robertson , Dr. Kullervo Hynynen , Dr. Lorne Zinman

Project description There is significant interest in the development of cellular replacement therapy for the treatment of Amyotrophic Lateral Sclerosis (Lou Geherig’s disease or ‘ALS’), a terminal illness that...


Identification of Nurr1/RXR complex agonists for neuroprotection

Grantees: Dr. Daniel Lévesque , Dr. Claude Rouillard

Project description Numerous scientific evidences converge to indicate that the transcription factor complex (modulator of gene expression) formed by Nurr1, and its partner retinoid X receptor (Nurr1/RXR), represents an...


GSK-3 disruption of neuronal firing synchrony in cortex and hippocampus: A new therapeutic approach

Grantees: Dr. Susan George , Dr. Melissa Perreault

Project description There exists a strong relationship between the coordinated activity of neural networks in specific regions of the brain, such as cortex and hippocampus, with learning and memory....


High-resolution memory-circuit biomarkers for identifying risk for Alzheimer’s disease

Grantees: Dr. Mallar Chakravarty , Dr. John Breitner , Dr. Pedro Rosa Neto , Dr. Jens Pruessner , Dr. Judes Poirier

Project description It is well known that patients suffering from Alzheimer’s disease present with an impairment in memory function.  It is also well known that individuals suffering from Alzheimer’s...


The LRRK2-WAVE2 Interaction: Immune-mediated Phagocytosis in Parkinson’s disease

Grantees: Dr. David Park

Project description Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It’s cause(s) are predominantly unknown, but exposure to harmful environmental factors (toxins or infections) can increase an...