Mechanisms of Cellular Death in Neurodegeneration (MCDN)

The “Mechanisms of cellular death in NeuroDegeneration” (MCDN) funding program’s overall goal is to discover and understand the mechanisms and pathophysiological processes by which brain cell loss is mediated in disease and thereby seek insights and potential targets for therapeutic interventions that would sustain healthy brain function.

MCDN Awardees

The Alzheimer’s Association (ALZ), Alzheimer’s Research UK (ARUK) and the Weston Brain Institute collaboratively funded the following two studies:

The Role of Peptidyl-prolyl Isomerases in Tau-mediated Neurotoxicity

Grantees: Dr. Chad A. Dickey

Background Tau protein plays an important role in Alzheimer’s and other neurodegenerative diseases. Tau protein’s normal function is to stabilize the internal scaffolding of cells and help transport nutrients....


Mechanisms of Neuronal Apoptosis Induced by the Early Pathogenic Cis P-tau

Grantees: Dr. Kun Ping Lu

Background A characteristic of Alzheimer’s and other neurodegenerative diseases is the accumulation of tau protein in the brain in the form of tangles. Tau protein, which normally helps nerve...