Early Phase Clinical Trials 2014

The Early Phase Clinical Trials program provides support for Phase I and IIa clinical trials for therapeutics of neurodegenerative diseases of aging. Projects each receive up to $1,500,000  over up to 4 years.

Early Phase Clinical Trials 2014 Program Materials

Early Phase Clinical Trials 2014 Awardees

Proof of Concept Trial of Probucol, an Inducer of apoE, for Prevention of Alzheimer’s Dementia

Grantees: Dr. John Breitner , Dr. Judes Poirier , Dr. Serge Gauthier , Dr. Pedro Rosa Neto , Dr. Alan Evans , Dr. Pierre Etienne , Dr. Louis Collins , Dr. Pierre Bellec , Dr. Gerhard Multhaup , Dr. Rick Hoge

Project description Scores of clinical trials have failed to find drugs for the treatment of Alzheimer’s disease (AD) dementia. Newer trials are seeking ways to postpone or prevent onset...


Investigating the efficacy of high-frequency rTMS treatment for Alzheimer’s disease

Grantees: Dr. Zahra Kazem-Moussavi , Dr. Colleen Milliken , Dr. Lisa Koski , Dr. Lesley Fellows , Dr. Paul Fitzgerald , Dr. Mandana Modirrousta , Dr. Xikui Wang , Dr. Behzad Mansouri , Dr. Craig Omelan

Project description Alzheimer’s disease has no known cure and is called the pandemic of the century. Transcranial Magnetic Stimulation (TMS) is a safe and non-invasive procedure, in which a...