Transformational Research 2014

The goal of the Program is to provide funding to high potential, translational research that will have transformational impact in neurodegenerative diseases of aging.  These are to be larger, longer grants (up to $1.5m for up to 3 years) for transformational work including international collaborations.

Transformational Research 2014 Program Materials

Transformational 2014 Awardees

CHIMERA: A transformational model of rodent traumatic brain injury

Grantees: Dr. Cheryl Wellington , Dr. Peter Cripton

Project description One important but poorly understood risk factor for dementia is a history of brain injury, including concussion. Studies in professional football players who have had hundreds of...


Tau imaging in parkinsonian disorders

Grantees: Dr. A. Jon Stoessl , Dr. Silke Appel-Cresswell , Dr. Vesna Sossi , Dr. Makoto Higuchi , Dr. Paul Schaffer , Dr. Hitoshi Shinotoh

Project description We plan to use positron emission tomography (PET) to differentiate between Parkinson’s disease (PD) and other conditions that cause features of parkinsonism but which have different pathology,...


Novel technology for early detection of Alzheimer’s disease – clinical prototypes

Grantees: Dr. Mitchell Albert , Dr. Alla Reznik , Dr. Seda Rafilovich , Dr. Ayman Hassan

Project description Alzheimer’s disease (AD) is an incurable disease caused by the degeneration of brain cells, affecting more than 20 million people globally. Development of effective drugs for treatment...


Filling gaps in alpha-synuclein related dementias: Identifying critical biomarkers or cognitive conversion in the sphingolipidome

Grantees: Dr. Steffany Bennett , Dr. Michael Schlossmacher , Dr. Julianna Tomlinson , Dr. Carolina Cieniak , Dr. Stephen Gomperts , Dr. Britt Mollenhauer , Dr. John Woulfe

Project description The differential diagnosis of Dementia with Lewy Bodies, Parkinson’s Disease with Dementia or of Parkinson’s Disease (without any Dementia) rests on clinical observations alone. ‘State, rate, fate,...


Calcium homeostasis in Parkinson’s disease: Letm1 as a therapeutic target

Grantees: Dr. David Park

Project description Parkinson’s disease (PD) is a progressive, neurodegenerative disorder that predominantly affects the aging population. Although its causes remain unknown, ~10% of PD cases are linked to genetic...