Dr. Romina Mizrahi

Clinician Scientist, Research Imaging Centre, Centre for Addiction and Mental Health
Associate Professor, University of Toronto

mizrahiDr. Romina Mizrahi received her medical degree from the University of Buenos Aires, Argentina and her PhD from the University of Toronto, Canada. She specializes in Neuroscience, and PET imaging. Very early in her career, she received funding from the Canadian Institutes of Health Research (CIHR) to investigate stress-induced dopamine release in subjects at clinical high risk (CHR) for Schizophrenia (SCZ) and in antipsychotic naive SCZ. Both an operating grant and a New Investigator Award from CIHR enabled her to carry out a project which provided the first evidence of dopamine sensitization in both SCZ and CHR. Following this line of investigation, she also received Ontario Mental Health Foundation funding (both Operating Grant and New Investigator fellowship) to study cross-sensitization between stress and cannabis in these populations. With the support of the Scottish Rite Charitable Foundation and the Brain & Behaviour Research Foundation, she carried out the first human experiments with the novel radioligand to image neuroinflammation, [18F]-FEPPA, publishing both its validation and genetic contribution to binding very recently. She has great interest in applying this new methodology to clinical populations. Her well supported research has involved testing hypotheses generated from human postmortem and preclinical data using molecular imaging methods to study highly selected, mild cognitive impairment patients, as a unique opportunity to understand the earliest neurobiological changes that occur in Alzheimer’s disease (AD) that may lead to early detection and prevention of conversion to AD. The Centre for Addiction and Mental Health has provided her with a remarkable opportunity to collaborate with many investigators from diverse disciplines from neuropsychologist to physics and genetics. The collegial environment has fostered an interdisciplinary group of colleagues, many of whom serve as co-investigators on the proposed project.

Dr. Romina Mizrahi Grants