Dr. Peter St George-Hyslop

peter_st_george-hyslopDr. Peter St George-Hyslop is Director of the Tanz Centre for Research in Neurodegenerative Diseases and Professor at the University of Toronto. He is also a Professor of Experimental Neuroscience in the department of Clinical Neurosciences at the University of Cambridge, UK and Director of the Cambridge Dementia Biomedical Research Unit.

He is an internationally acclaimed geneticist and physician whose research on the genetics of Alzheimer’s disease has made a significant impact on the field of molecular and biochemical research. In addition to his work on Alzheimer’s disease, Dr. St George-Hyslop has made major contributions to the understanding of several other neurodegenerative diseases, such as Parkinson’s, and Frontotemporal Lobar Degeneration/Motor Neuron Disease.  His laboratory directly led to the discovery of multiple genes associated with Alzheimer’s disease including presenilin 1, presenilin 2, nicastrin, and SORL1.  He also co-led the discovery of the gene for the amyloid precursor protein. Mutations in critical regions of this protein cause familial susceptibility to Alzheimer’s disease by increasing the production of amyloid beta peptide. The amyloid beta can accumulate and form the amyloid plaques which are the hallmark of Alzheimer’s disease.

Work in Dr. St George-Hyslop’s group has led to the generation of several Alzheimer’s disease mouse models, which are used as screening tools for the discovery of new drugs. He used one of these mouse models to show that immunization with amyloid beta peptides reduces neuropathological and cognitive deficits in mice. This result has suggested that amyloid beta immunization, as well as other therapies directed at amyloid biology, may have utility as treatments and/or preventions of Alzheimer’s disease in humans. This idea has recently received support from some human trials, which have suggested partial benefit to patients with early/mild Alzheimer’s disease.

Dr. St George-Hyslop has published nearly 400 papers in leading peer-reviewed journals and is one of the most cited authors in the field of Alzheimer’s disease research. His research has earned numerous prestigious awards, such as the Dan David Prize in 2014, the BIAL Merit Award in Medical Sciences in 2013, the Howard Hughes Foundation International Scholar Award and the Premier’s Summit Award in Medical Research in 2007, the Oon International Prize in Preventative Medicine from the University of Cambridge in 2004, among many others.

Dr. St George-Hyslop received his medical degree from the University of Ottawa in 1976 and completed post-graduate work in internal medicine and neurology at the University of Toronto. He carried out post-doctoral research at Harvard Medical School where he also became an instructor in molecular genetics and neurology from 1987 to 1991.

Dr. Peter St George-Hyslop Grants