Dr. Julianna Tomlinson

Senior Research Associate, Ottawa Hospital Research Institute

Dr. Julianna Tomlinson received her PhD in Biochemistry from the University of Ottawa in 2007. She began her postdoctoral fellowship studying research topics related to Parkinson disease in the laboratory of Michael Schlossmacher at the Ottawa Hospital Research Institute. In 2011, she became a Senior Research Associate, working with Dr. Schlossmacher.

Julianna’s research interests have focused on the regulation of alpha–‐synuclein (SNCA). There are two main avenues: The first is on the study of the molecular mechanisms and pathways that regulate alpha–‐synuclein gene expression and the potential exploitation of these pathways for drug repositioning purposes. These studies were funded through two awards from the Parkinson Society Canada to Drs. Tomlinson and Schlossmacher.
Her second research interest has been in creating better mouse models of PD and SNCA–‐linked dementia including dementia with Lewy bodies (DLB). In 2013, the first SYNERGY mice and related control lines were born. These mice harbor the two most important genetic risk factors currently known in the development PD and DLB: mutations in Gba1 and elevated SNCA load. The goal in generating these mice was to create an enabling platform for cause–‐directed drug discovery in PD and DLB.

Dr. Julianna Tomlinson Grants